vintafolide indications/contra

Stem definitionDrug idCAS RN
vinca alkaloids 4831 742092-03-1

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vintafolide
  • EC145
  • vynfinit
has significant antiproliferative activity and tolerability, thus lending support to an ongoing phase 1 trial for the treatment of advanced malignancies
  • Molecular weight: 1917.06
  • Formula: C86H109N21O26S2
  • CLOGP: 0
  • LIPINSKI: 3
  • HAC: 47
  • HDO: 23
  • TPSA: 716.39
  • ALOGS: -5.16
  • ROTB: 44

Drug dosage:

None

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

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SourceCodeDescription
ATC L01CA06 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
ANTINEOPLASTIC AGENTS
PLANT ALKALOIDS AND OTHER NATURAL PRODUCTS
Vinca alkaloids and analogues

Drug Use (View source of the data)

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DiseaseRelationSNOMED_IDDOID
Malignant epithelial tumor of ovary indication 254849005

Acid dissociation constants calculated using MoKa v3.0.0

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Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.83 acidic
pKa2 3.16 acidic
pKa3 3.61 acidic
pKa4 3.93 acidic
pKa5 4.65 acidic
pKa6 8.29 acidic
pKa7 12.85 acidic
pKa8 13.08 acidic
pKa9 13.33 acidic
pKa10 13.52 acidic
pKa11 13.79 acidic
pKa12 13.81 acidic
pKa13 10.75 Basic
pKa14 7.38 Basic
pKa15 6.76 Basic
pKa16 5.31 Basic
pKa17 4.44 Basic
pKa18 4.21 Basic
pKa19 2.14 Basic
pKa20 1.73 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

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IDSource
CHEBI:134736 CHEBI
D10434 KEGG_DRUG
36O410ZD4I UNII
9564 INN_ID
C520389 MESH_SUPPLEMENTAL_RECORD_UI
DB05168 DRUGBANK_ID
CHEMBL3039521 ChEMBL_ID

Pharmaceutical products:

None